Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519322 | 0.91 | CA2 (0.56) | KDM4EKMT2AEGFRP4HTMALDH1A1 | |
| SCHEMBL9519106 | 0.91 | EGFR (0.50) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9519123 | 0.89 | P4HTM (0.48) | KDM4EKMT2AEGFRP4HTMALDH1A1 | |
| SCHEMBL9519608 | 0.88 | EGFR (0.44) | KDM4EKMT2AEGFRP4HTMALDH1A1 | |
| SCHEMBL9517068 | 0.88 | CASP3 (0.47) | KDM4EKMT2AP4HTMALDH1A1SMN1; SMN2 | |
| SCHEMBL9518026 | 0.86 | HPGD (0.51) | KDM4EKMT2AEGFRP4HTMALDH1A1 | |
| SCHEMBL9517944 | 0.85 | EGFR (0.49) | KMT2AEGFRP4HTMALDH1A1LMNA | |
| SCHEMBL27401721 | 0.85 | MAPT (0.48) | KDM4EEGFRP4HTMALDH1A1CYP3A4 | |
| SCHEMBL9519310 | 0.84 | EGFR (0.51) | EGFRP4HTMALDH1A1FLT1FLT4 | |
| SCHEMBL9517947 | 0.84 | NPC1 (0.56) | KMT2AALDH1A1LMNANFKB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |