Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517944 | 0.90 | EGFR (0.49) | EGFRP4HTMALDH1A1PTGS2FLT1 | |
| SCHEMBL9517993 | 0.87 | PTGS2 (0.59) | EGFRP4HTMALDH1A1PTGS2FLT1 | |
| SCHEMBL9519106 | 0.86 | EGFR (0.50) | EGFRP4HTMPTGS2FLT1FLT4 | |
| SCHEMBL9518008 | 0.85 | P4HTM (0.54) | EGFRP4HTMALDH1A1BCL2L1MCL1 | |
| SCHEMBL9515549 | 0.84 | KDM4E (0.52) | EGFRP4HTMALDH1A1PTGS2FLT1 | |
| SCHEMBL9517200 | 0.84 | P4HTM (0.70) | EGFRP4HTMPTGS2FLT1FLT4 | |
| SCHEMBL9518006 | 0.84 | P4HTM (0.67) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9515821 | 0.84 | POLB (0.49) | EGFRP4HTMALDH1A1CA1CA2 | |
| SCHEMBL9517002 | 0.83 | ATM (0.49) | EGFRP4HTMALDH1A1CA1CA2 | |
| SCHEMBL9515565 | 0.83 | BCL2L1 (0.53) | EGFRP4HTMBCL2L1MCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |