Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515454 | 0.86 | NPSR1 (0.45) | POLBGAANPSR1PIK3CAKDM4E | |
| SCHEMBL8490703 | 0.82 | SMN1; SMN2 (0.43) | POLBGAANPSR1KDM4EALDH1A1 | |
| SCHEMBL5734450 | 0.78 | POLB (0.41) | POLBGAANPSR1PIK3CAKDM4E | |
| Bromide SCHEMBL5734269 | 0.77 | POLB (0.41) | POLBGAANPSR1PIK3CAKDM4E | |
| SCHEMBL9300884 | 0.76 | POLB (0.47) | POLBGAANPSR1PIK3CAKDM4E | |
| SCHEMBL9299066 | 0.75 | POLB (0.43) | POLBGAANPSR1PIK3CAKDM4E | |
| SCHEMBL7427899 | 0.75 | POLB (0.41) | POLBGAANPSR1PIK3CAKDM4E | |
| SCHEMBL8489042 | 0.74 | GAA (0.40) | POLBGAANPSR1KDM4EALDH1A1 | |
| SCHEMBL9697181 | 0.73 | SMN1; SMN2 (0.43) | POLBGAANPSR1KDM4EALDH1A1 | |
| SCHEMBL9248248 | 0.73 | ALDH1A1 (0.45) | POLBGAANPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284338-B1 | Anti-tumour agents | ICI PLC (GB) | 1993-12-22 | — | — | EP | disclosed |
| US-4981856-A | QUINAZOLINE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-01 | — | — | US | disclosed |
| EP-0284338-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-28 | — | — | EP | disclosed |