Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515896 | 1.00 | SIRT1 (0.49) | SIRT1ALOX5EPHX2MAPTKMT2A | |
| SCHEMBL9642574 | 0.78 | MEN1 (0.52) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9642572 | 0.78 | MEN1 (0.52) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9514448 | 0.77 | ALOX5 (0.53) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9514441 | 0.77 | POLB (0.56) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9514406 | 0.77 | ALOX5 (0.48) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL10720978 | 0.77 | ALOX5 (0.48) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL12880505 | 0.76 | PTPN1 (0.59) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9518116 | 0.75 | ALOX5 (0.46) | ALOX5EPHX2MAPTKMT2AKDM4E | |
| SCHEMBL9518105 | 0.75 | ALOX5 (0.46) | ALOX5EPHX2MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219436-B1 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI CHEM IND (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-4902700-A | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-20 | — | — | US | disclosed |
| EP-0219436-A2 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1987-04-22 | — | — | EP | disclosed |