Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446324 | 1.00 | CA1 (0.47) | CA1CA2ALDH1A1ZDHHC7MAPT | |
| SCHEMBL12309039 | 1.00 | CA1 (0.47) | CA1CA2ALDH1A1ZDHHC7MAPT | |
| SCHEMBL2152481 | 0.92 | ZDHHC7 (0.50) | CA1CA2ZDHHC7ACHETSHR | |
| SCHEMBL31110294 | 0.92 | ZDHHC7 (0.50) | CA1CA2ZDHHC7ACHETSHR | |
| SCHEMBL28973678 | 0.92 | ZDHHC7 (0.50) | CA1CA2ZDHHC7ACHETSHR | |
| SCHEMBL3030911 | 0.87 | CA1 (0.41) | CA1CA2ALDH1A1ZDHHC7MAPT | |
| SCHEMBL9634932 | 0.87 | CA1 (0.41) | CA1CA2ALDH1A1ZDHHC7MAPT | |
| SCHEMBL13715542 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTATMACHEHPGD | |
| SCHEMBL445760 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTATMACHEHPGD | |
| SCHEMBL14570068 | 0.83 | ALDH1A1 (0.45) | ALDH1A1ATMHPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497385-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130123518-A1 | Bryostatin Analogues, Synthetic Methods and Uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-11-04 | — | — | US | disclosed |
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2007-11-22 | — | — | US | disclosed |
| US-7271185-B2 | Optically active azole derivative and process for producing the same | MITSUI CHEMICALS, INC. (JP) | 2007-09-18 | — | — | US | disclosed |
| US-7256286-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-08-14 | — | — | US | disclosed |
| EP-0277815-B1 | Optically active-2-alkoxy-propyl ether and liquid crystal composition | CHISSO CORP (JP) | 1993-11-24 | — | — | EP | disclosed |
| US-5021191-A | Ferroelectricity display elements; extremely small redution in crystal temperature region | CHISSO CORPORATION (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0277815-A2 | Optically active-2-alkoxy-propyl ether and liquid crystal composition | Chisso Corporation (JP) | 1988-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | PBK, TK1, BAK1 | CA1 4651/4885CA2 4778/4885ALDH1A1 4526/4885 |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | BID, HASPIN, HPGDS | CA1 3872/4885CA2 4747/4885ALDH1A1 4478/4885 |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | MCL1, PBK, BID | CA1 4101/4885CA2 4764/4885ALDH1A1 4749/4885 |
| US-20130123518-A1 | Bryostatin Analogues, Synthetic Methods and Uses | MCL1, PBK, BID | CA1 4101/4885CA2 4764/4885ALDH1A1 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.