Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691690 | 0.81 | METAP2 (0.39) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL4959250 | 0.80 | METAP2 (0.36) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL1079071 | 0.75 | METAP2 (0.41) | METAP2METAP1ENPP1 | |
| SCHEMBL3044434 | 0.73 | METAP2 (0.35) | METAP2METAP1ENPP1 | |
| SCHEMBL9936013 | 0.73 | METAP2 (0.44) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL9572857 | 0.73 | METAP2 (0.44) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL4957389 | 0.73 | METAP2 (0.44) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL3054572 | 0.71 | METAP2 (0.34) | METAP2METAP1ENPP1 | |
| SCHEMBL1443066 | 0.70 | METAP2 (0.42) | METAP2METAP1ENPP1 | |
| SCHEMBL6485 | 0.70 | METAP2 (0.42) | METAP2METAP1ENPP1ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338887-B1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMA (US) | 1993-12-08 | — | — | EP | disclosed |
| EP-0338887-A1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-25 | — | — | EP | disclosed |