Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959250 | 0.82 | METAP2 (0.36) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL9516035 | 0.81 | METAP2 (0.35) | METAP2METAP1ENPP1ITGB3ITGAV | |
| SCHEMBL1079071 | 0.81 | METAP2 (0.41) | METAP2METAP1NPY5RENPP1 | |
| SCHEMBL9572857 | 0.78 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL6485 | 0.76 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL1551604 | 0.75 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL9936013 | 0.75 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL4955472 | 0.72 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL29208955 | 0.72 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL30884953 | 0.72 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294074-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-04-08 | — | — | EP | disclosed |
| US-4851412-A | ASTHMA, ARTHRITIS | PFIZER INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0294074-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-12-07 | — | — | EP | disclosed |