Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517516 | 0.79 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL42386 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL9847609 | 0.78 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9779493 | 0.77 | CHRM1 (0.50) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL19027653 | 0.77 | ROCK2 (0.35) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9514953 | 0.77 | CHRM1 (0.54) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL12289981 | 0.73 | — | — | |
| SCHEMBL9514823 | 0.71 | CHRM1 (0.50) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL971151 | 0.70 | CA12 (0.44) | ALDH1A1HPGD | |
| SCHEMBL2918727 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411615-B1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER LAMBERT CO (US) | 1993-12-29 | — | — | EP | claimed |
| EP-0411615-A1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER-LAMBERT COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| US-4988688-A | Cognitive activators | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | claimed |
| EP-0411615-B1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER LAMBERT CO (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0411615-A1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER-LAMBERT COMPANY (US) | 1991-02-06 | — | — | EP | disclosed |
| US-4988688-A | Cognitive activators | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |