Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228875 | 0.75 | POLB (0.44) | POLBFAAH | |
| SCHEMBL16787788 | 0.70 | GBA1 (0.56) | POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8403545 | 0.70 | POLB (0.61) | POLBLMNAALDH1A1KMT2A | |
| SCHEMBL6814764 | 0.67 | POLB (0.51) | POLBFAAH | |
| SCHEMBL9516553 | 0.65 | MAPT (0.65) | MAPTSMN1; SMN2LMNAHIF1AMEN1 | |
| SCHEMBL10775630 | 0.64 | POLB (0.55) | POLBALDH1A1KMT2A | |
| SCHEMBL4573389 | 0.63 | POLB (0.46) | POLBMAPTLMNAALDH1A1CYP2C9 | |
| SCHEMBL8277240 | 0.62 | CA2 (0.62) | POLBMAPTLMNAHIF1AMEN1 | |
| SCHEMBL5536012 | 0.62 | POLB (0.53) | POLBLMNAALDH1A1KMT2A | |
| SCHEMBL4455 | 0.62 | CA2 (0.62) | POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236624-B1 | SUBSTITUTED PHENYL ETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-08-11 | — | — | EP | disclosed |