Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150234 | 0.88 | AOC3 (0.48) | AOC3IDO1NOS2MEN1KMT2A | |
| SCHEMBL27726392 | 0.81 | MAPT (0.44) | AOC3IDO1CHRNB2CHRNA4HPGD | |
| SCHEMBL27747207 | 0.81 | MAPT (0.44) | AOC3IDO1CHRNB2CHRNA4HPGD | |
| SCHEMBL2944466 | 0.79 | GABBR2 (0.48) | NOS2CHRNB2CHRNA4 | |
| SCHEMBL10860685 | 0.78 | AOC3 (0.67) | AOC3IDO1NOS2CHRNB2CHRNA4 | |
| SCHEMBL28622675 | 0.77 | AOC3 (0.47) | AOC3IDO1MEN1KMT2AACP3 | |
| SCHEMBL10727832 | 0.77 | CHRNB2 (0.48) | AOC3IDO1NOS2MEN1KMT2A | |
| SCHEMBL28622677 | 0.77 | AOC3 (0.47) | AOC3IDO1MEN1KMT2AACP3 | |
| SCHEMBL21848091 | 0.77 | NOS2 (0.44) | AOC3IDO1NOS2PARP1 | |
| Hydrochloric Acid SCHEMBL31332740 | 0.77 | AOC3 (0.65) | AOC3IDO1NOS2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236624-B1 | SUBSTITUTED PHENYL ETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-08-11 | — | — | EP | disclosed |
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |