Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519314 | 0.95 | EGFR (0.37) | EGFRP4HTMADRB2ADRB1ADRB3 | |
| SCHEMBL9519674 | 0.91 | EGFR (0.43) | EGFRP4HTMADRB2ADRB1ADRB3 | |
| SCHEMBL9515755 | 0.89 | EGFR (0.39) | EGFRP4HTMADRB2ADRB1ADRB3 | |
| SCHEMBL9515897 | 0.86 | EGFR (0.42) | EGFRP4HTMADRB2ADRB1ADRB3 | |
| SCHEMBL9515637 | 0.85 | EPHX2 (0.38) | P4HTMMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9516716 | 0.83 | EPHX2 (0.36) | P4HTMADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL9516279 | 0.82 | HIF1A (0.39) | P4HTMHDAC6PTGS1HDAC1HDAC4 | |
| SCHEMBL9519439 | 0.81 | PNMT (0.42) | HDAC6HDAC1 | |
| SCHEMBL9516977 | 0.80 | EGFR (0.44) | EGFRP4HTMMEN1NPC1RAB9A | |
| SCHEMBL9518016 | 0.80 | MEN1 (0.38) | P4HTMMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |