Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515755 | 0.91 | EGFR (0.39) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9519674 | 0.89 | EGFR (0.43) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9518022 | 0.89 | HDAC6 (0.39) | P4HTMPTGS1PTGS2MEN1NPC1 | |
| SCHEMBL9515897 | 0.88 | EGFR (0.42) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9517265 | 0.86 | EGFR (0.41) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9515773 | 0.86 | HSD11B1 (0.43) | P4HTMPTGS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9517939 | 0.85 | EGFR (0.40) | EGFRP4HTMNPC1RAB9AHTT | |
| SCHEMBL9516886 | 0.83 | MMP1 (0.40) | NPC1RAB9AKMT2A | |
| SCHEMBL9515738 | 0.83 | P4HTM (0.43) | EGFRP4HTMMEN1NPC1RAB9A | |
| SCHEMBL9517030 | 0.81 | SLC6A9 (0.39) | P4HTMMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |