Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811886 | 0.85 | MEN1 (0.50) | POLBMEN1KMT2ATDP1BLM | |
| SCHEMBL23582938 | 0.84 | PLA2G4B (0.55) | MEN1KMT2ARAB9AMAPT | |
| SCHEMBL14939906 | 0.84 | ALOX15 (0.57) | POLBMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL23582929 | 0.83 | MEN1 (0.54) | MEN1KMT2ATDP1RAB9AL3MBTL1 | |
| SCHEMBL10506137 | 0.82 | MEN1 (0.58) | POLBMEN1KMT2ATDP1BLM | |
| SCHEMBL9450347 | 0.82 | MEN1 (0.49) | POLBMEN1KMT2ATDP1BLM | |
| SCHEMBL1480561 | 0.81 | RXRA (0.53) | KMT2ARAB9ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL8879627 | 0.81 | POLB (0.53) | POLBMEN1KMT2ATDP1RAB9A | |
| SCHEMBL11196500 | 0.80 | NPSR1 (0.51) | MEN1KMT2ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13839306 | 0.80 | PLA2G4B (0.46) | MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236624-B1 | SUBSTITUTED PHENYL ETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-08-11 | — | — | EP | disclosed |
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |