Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23582938 | 0.84 | PLA2G4B (0.55) | MEN1RAB9AKMT2AMAPTTP53 | |
| SCHEMBL10506137 | 0.82 | MEN1 (0.58) | MEN1RAB9AKMT2ATDP1POLB | |
| SCHEMBL9517796 | 0.82 | POLB (0.54) | MEN1RAB9AKMT2ATDP1POLB | |
| SCHEMBL14546296 | 0.81 | MEN1 (0.47) | MEN1RAB9AKMT2ATDP1POLB | |
| SCHEMBL14111320 | 0.79 | ALOX5 (0.42) | RAB9ASMN1; SMN2PARP10 | |
| SCHEMBL3371954 | 0.79 | MEN1 (0.51) | MEN1RAB9AKMT2ATDP1POLB | |
| SCHEMBL11216007 | 0.79 | MEN1 (0.49) | MEN1RAB9AKMT2ATDP1POLB | |
| SCHEMBL16622219 | 0.79 | FFAR1 (0.51) | TDP1BLM | |
| SCHEMBL23582929 | 0.79 | MEN1 (0.54) | MEN1RAB9AKMT2ATDP1L3MBTL1 | |
| SCHEMBL9449852 | 0.78 | CA2 (0.64) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |