Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515803 | 0.93 | P4HTM (0.49) | P4HTMGABRA5L3MBTL1MEN1NPC1 | |
| SCHEMBL9517966 | 0.86 | P4HTM (0.45) | P4HTMGABRA5PTPN1CXCR2MMP3 | |
| SCHEMBL9515950 | 0.85 | GABRA5 (0.40) | P4HTMGABRA5L3MBTL1MEN1NPC1 | |
| SCHEMBL9516030 | 0.84 | GABRA5 (0.44) | P4HTMGABRA5L3MBTL1MEN1NPC1 | |
| SCHEMBL9517881 | 0.82 | GABRA5 (0.53) | P4HTMGABRA5MEN1NPC1RAB9A | |
| SCHEMBL9517942 | 0.81 | P4HTM (0.47) | P4HTMGABRA5PTPN1CXCR2BCL2L1 | |
| SCHEMBL9519639 | 0.81 | P4HTM (0.47) | P4HTMGABRA5L3MBTL1PTPN1CXCR2 | |
| SCHEMBL9517031 | 0.81 | P4HTM (0.39) | P4HTMGABRA5L3MBTL1MEN1NPC1 | |
| SCHEMBL9517010 | 0.79 | P4HTM (0.47) | P4HTMGABRA5PTPN1CXCR2BCL2L1 | |
| SCHEMBL9517984 | 0.78 | GABRA5 (0.42) | P4HTMGABRA5L3MBTL1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |