Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.47 |
| ▸ | METAP1 | P53582 | 7/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518165 | 1.00 | METAP2 (0.47) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL9516061 | 0.80 | METAP2 (0.49) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL9516057 | 0.80 | METAP2 (0.49) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9504651 | 0.78 | METAP2 (0.43) | METAP2METAP1CTSSCTSLCTSB | |
| SCHEMBL9506681 | 0.78 | METAP2 (0.43) | METAP2METAP1CTSSCTSLCTSB | |
| Hydrochloric Acid SCHEMBL9514955 | 0.78 | METAP2 (0.47) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL9514952 | 0.78 | METAP2 (0.47) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9694637 | 0.77 | TACR1 (0.39) | METAP2METAP1CTSSCTSLCTSB | |
| SCHEMBL15187941 | 0.76 | CYP3A4 (0.44) | CYP2C9CYP2C19 | |
| SCHEMBL27687048 | 0.74 | CTSS (0.41) | METAP2METAP1CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266950-B1 | Nor-statine and nor-cyclostatine polypeptides | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |