Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13022054 | 0.79 | MAPT (0.43) | GAAMEN1KMT2AMAPTTSHR | |
| SCHEMBL409920 | 0.79 | MAPT (0.43) | GAAMEN1KMT2AMAPTMMP1 | |
| SCHEMBL2844045 | 0.79 | MAPT (0.43) | GAAMEN1KMT2AMAPTMMP1 | |
| SCHEMBL28287137 | 0.77 | MAPT (0.42) | GAAMEN1KMT2AMAPTMMP1 | |
| SCHEMBL28237924 | 0.75 | MAPT (0.41) | GAAMEN1KMT2AMAPTMMP1 | |
| SCHEMBL7455288 | 0.75 | MMP1 (0.46) | GAAMEN1KMT2AMAPTMMP1 | |
| SCHEMBL1276983 | 0.73 | MAPT (0.46) | GAAMEN1KMT2AMAPTTSHR | |
| SCHEMBL15443902 | 0.72 | KMT2A (0.56) | GAAMEN1KMT2AMAPTTSHR | |
| SCHEMBL14417614 | 0.71 | GAA (0.38) | GAAMEN1KMT2AMAPTTSHR | |
| SCHEMBL29727668 | 0.70 | MAPT (0.45) | GAAMEN1KMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266950-B1 | Nor-statine and nor-cyclostatine polypeptides | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |