Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 8/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518298 | 1.00 | HMGCR (0.59) | HMGCRRIPK2PTGS1PTGS2GLA | |
| SCHEMBL9518373 | 0.88 | HMGCR (0.58) | HMGCRRIPK2PTGS1PTGS2GLA | |
| SCHEMBL9518598 | 0.83 | HMGCR (0.56) | HMGCRRIPK2MAPK13EGFRCSNK1D | |
| SCHEMBL9750945 | 0.78 | HMGCR (0.56) | HMGCRPTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL9518437 | 0.78 | HMGCR (0.56) | HMGCRPTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL9750729 | 0.76 | HMGCR (0.58) | HMGCRGLAPOLB | |
| SCHEMBL9750985 | 0.75 | HMGCR (1.00) | HMGCR | |
| SCHEMBL9521396 | 0.75 | HMGCR (0.68) | HMGCR | |
| SCHEMBL9521499 | 0.75 | HMGCR (0.62) | HMGCRRIPK2GLAPOLB | |
| SCHEMBL9518620 | 0.75 | HMGCR (0.80) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |