Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 7/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750729 | 0.81 | HMGCR (0.58) | HMGCRGLAPOLB | |
| SCHEMBL9518373 | 0.79 | HMGCR (0.58) | HMGCRGLAPOLBRIPK2 | |
| SCHEMBL9750923 | 0.77 | HMGCR (1.00) | HMGCR | |
| SCHEMBL9750803 | 0.76 | HMGCR (0.49) | HMGCRGLAPOLBRIPK2 | |
| SCHEMBL9518306 | 0.76 | HMGCR (0.81) | HMGCR | |
| SCHEMBL9518177 | 0.75 | HMGCR (0.47) | HMGCRGCGR | |
| SCHEMBL9518298 | 0.75 | HMGCR (0.59) | HMGCRGLAPOLBRIPK2 | |
| SCHEMBL9518290 | 0.75 | HMGCR (0.59) | HMGCRGLAPOLBRIPK2 | |
| SCHEMBL9518598 | 0.74 | HMGCR (0.56) | HMGCRRIPK2 | |
| SCHEMBL9750938 | 0.73 | HMGCR (0.51) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300657-B1 | 4-SUBSTITUTED 3-OXOBUTANOATE ESTER DERIVATIVES | MERCK & CO. INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |