Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10750896 | 0.89 | PTGS1 (0.50) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL3675412 | 0.84 | PTGS1 (0.53) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL10750729 | 0.84 | FAAH (0.46) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL11488327 | 0.82 | PTGS1 (0.52) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL6675858 | 0.81 | PTGS1 (0.50) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL10747854 | 0.81 | GSK3B (0.52) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL3395331 | 0.81 | CA2 (0.50) | PTGS1LMNATSHRALDH1A1HPGD | |
| SCHEMBL1966513 | 0.80 | CXCR1 (0.53) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL21064585 | 0.79 | PTGS1 (0.57) | PTGS1PTGS2LMNAALOX5CYP2C9 | |
| SCHEMBL25477242 | 0.79 | PTGS1 (0.49) | PTGS1PTGS2LMNAALOX5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118209666-A | Method for detecting ibuprofen intermediate isomer | 山东新华制药股份有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-111879880-B | Method for detecting 3 intermediates in ibuprofen | 珠海润都制药股份有限公司 | 2022-08-23 | — | — | CN | claimed |
| JP-58010525-A | — | — | None | — | — | JP | disclosed |
| CN-118209666-A | Method for detecting ibuprofen intermediate isomer | 山东新华制药股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-118209666-A | Method for detecting ibuprofen intermediate isomer | 山东新华制药股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-117342938-A | Preparation method of ibuprofen | 常州大学 | 2024-01-05 | — | — | CN | disclosed |
| US-11826726-B2 | Active zinc-based catalyst and preparation method thereof, and use in catalyzing rearrangement reaction of ibuprofen | QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-11-28 | — | — | US | disclosed |
| US-11826726-B2 | Active zinc-based catalyst and preparation method thereof, and use in catalyzing rearrangement reaction of ibuprofen | QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-11-28 | — | — | US | disclosed |
| US-20230311096-A1 | ACTIVE ZINC-BASED CATALYST AND PREPARATION METHOD THEREOF, AND USE IN CATALYZING REARRANGEMENT REACTION OF IBUPROFEN | QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-10-05 | — | — | US | disclosed |
| US-20230311096-A1 | ACTIVE ZINC-BASED CATALYST AND PREPARATION METHOD THEREOF, AND USE IN CATALYZING REARRANGEMENT REACTION OF IBUPROFEN | QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-10-05 | — | — | US | disclosed |
| CN-116425698-B | Methylthiazole compound and preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2023-08-29 | — | — | CN | disclosed |
| US-4539420-A | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-09-03 | — | — | US | disclosed |
| EP-0151702-A2 | Alpha-hydroxyketone acetals | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-08-21 | — | — | EP | disclosed |
| EP-0034871-B1 | PROCESS FOR PREPARING ESTERS OF ALKANOIC ACIDS VIA REARRANGEMENT OF ALPHA-HALOKETALS | BLASCHIM S.p.A. (IT) | 1985-07-31 | — | — | EP | disclosed |
| EP-0071299-B1 | PROCESS FOR PREPARING ALKANOIC ACIDS OR ESTERS THEREOF BY REARRANGEMENT OF ALPHA-HALO-KETONES IN PROTIC MEDIUM AND IN THE PRESENCE OF A NON-NOBLE METAL SALT | BLASCHIM S.p.A. (IT) | 1984-10-31 | — | — | EP | disclosed |
| EP-0071299-A1 | Process for preparing alkanoic acids or esters thereof by rearrangement of alpha-halo-ketones in protic medium and in the presence of a non-noble metal salt | BLASCHIM S.p.A. (IT) | 1983-02-09 | — | — | EP | disclosed |
| JP-S5810525-A | PREPARATION OF OPTICAL ACTIVE 1-AROMATIC GROUP-SUBSTITUTED-1-ALKANONES | SAGAMI CHEM RES CENTER | 1983-01-21 | — | — | JP | disclosed |
| EP-0067698-A2 | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-12-22 | — | — | EP | disclosed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | disclosed |
| EP-0034871-A2 | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals | BLASCHIM S.p.A. (IT) | 1981-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11826726-B2 | Active zinc-based catalyst and preparation method thereof, and use in catalyzing rearrangement reaction of ibuprofen | SOD1, ZNF787, CDK6 | PTGS1 61/4885PTGS2 83/4885LMNA 2566/4885 |
| US-20230311096-A1 | ACTIVE ZINC-BASED CATALYST AND PREPARATION METHOD THEREOF, AND USE IN CATALYZING REARRANGEMENT REACTION OF IBUPROFEN | SOD1, ZNF787, CDK6 | PTGS1 61/4885PTGS2 83/4885LMNA 2566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.