Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11639674 | 0.98 | CYP2D6 (0.48) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL2728837 | 0.95 | THRB (0.46) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL18220751 | 0.84 | ACE (0.54) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL13465759 | 0.83 | CYP2D6 (0.65) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL6286943 | 0.83 | CYP2D6 (0.49) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL11265157 | 0.83 | CYP2D6 (0.49) | CYP2D6ALDH1A1THRBKDM4EHSD17B10 | |
| SCHEMBL28566831 | 0.80 | THRB (0.41) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL10780118 | 0.79 | CYP2D6 (0.59) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL14809033 | 0.79 | CYP2D6 (0.44) | CYP2D6ALDH1A1USP2LMNAPOLB | |
| SCHEMBL15407007 | 0.79 | THRB (0.56) | CYP2D6ALDH1A1THRBKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170158637-A1 | Synthetic Processes of Carprofen | CHEMWERTH, INC. | 2017-06-08 | — | — | US | disclosed |
| US-9611217-B2 | Synthetic processes of carprofen | CHEMWERTH, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160326113-A1 | Synthetic Processes of Carprofen | CHEMWERTH, INC. | 2016-11-10 | — | — | US | disclosed |
| EP-3091000-A1 | SYNTHETIC PROCESS OF CARPROFEN | ChemWerth, Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| EP-0239306-B1 | TETRAHYDROCARBAZOLE ESTERS | MERCK FROSST CANADA INC. (CA) | 1993-06-02 | — | — | EP | disclosed |
| US-4940719-A | Tetrahydrocarbazole esters, pharmaceutical compositions and use | MERCK FROSST CANADA, INC. (CA) | 1990-07-10 | — | — | US | disclosed |
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0239306-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1987-09-30 | — | — | EP | disclosed |
| EP-0234708-A1 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1987-09-02 | — | — | EP | disclosed |
| US-4128560-A | Tricyclic alkylamine derivatives | AYERST MCKENNA & HARRISON LTD. (CA) | 1978-12-05 | — | — | US | disclosed |
| US-4057559-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326113-A1 | Synthetic Processes of Carprofen | CYP4F2, CYP4F3, CYP2J2 | CYP2D6 26/4885ALDH1A1 766/4885USP2 3397/4885 |
| US-20170158637-A1 | Synthetic Processes of Carprofen | CYP4F2, CYP4F3, CYP2J2 | CYP2D6 26/4885ALDH1A1 766/4885USP2 3397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.