Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607337 | 0.83 | CYP2D6 (0.65) | CYP2D6ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL5096916 | 0.83 | CYP2D6 (0.65) | CYP2D6ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL5607333 | 0.83 | CYP2D6 (0.65) | CYP2D6ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL11265157 | 0.83 | CYP2D6 (0.49) | CYP2D6THRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9518399 | 0.83 | CYP2D6 (0.49) | CYP2D6THRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11639674 | 0.81 | CYP2D6 (0.48) | CYP2D6THRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10780118 | 0.79 | CYP2D6 (0.59) | CYP2D6THRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15407007 | 0.79 | THRB (0.56) | CYP2D6THRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6287504 | 0.78 | CYP2D6 (0.43) | CYP2D6ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL2728837 | 0.77 | THRB (0.46) | CYP2D6THRBALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858743-B2 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO, KG (AT) | 2005-02-22 | — | — | US | claimed |
| EP-1286981-B1 | METHOD FOR THE PRODUCTION OF 2- COUMARONE AND SUBSTITUTED 2-COUMARONES | DSM FINE CHEM AUSTRIA GMBH (AT) | 2004-08-04 | — | — | EP | claimed |
| US-20030171601-A1 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-09-11 | — | — | US | claimed |
| CN-1434815-A | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2003-08-06 | — | — | CN | claimed |
| CN-1202102-C | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2005-05-18 | — | — | CN | disclosed |
| US-6858743-B2 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO, KG (AT) | 2005-02-22 | — | — | US | disclosed |
| US-6858743-B2 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO, KG (AT) | 2005-02-22 | — | — | US | disclosed |
| EP-1286981-B1 | METHOD FOR THE PRODUCTION OF 2- COUMARONE AND SUBSTITUTED 2-COUMARONES | DSM FINE CHEM AUSTRIA GMBH (AT) | 2004-08-04 | — | — | EP | disclosed |
| US-20030171601-A1 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-09-11 | — | — | US | disclosed |
| US-20030171601-A1 | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-09-11 | — | — | US | disclosed |
| CN-1434815-A | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2003-08-06 | — | — | CN | disclosed |
| CN-1434815-A | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2003-08-06 | — | — | CN | disclosed |
| EP-1286981-A1 | METHOD FOR THE PRODUCTION OF 2- COUMARONE AND SUBSTITUTED 2-COUMARONES | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001094329-A8 | METHOD FOR THE PRODUCTION OF 2- COUMARONE AND SUBSTITUTED 2-COUMARONES | DSM FINE CHEM AUSTRIA GMBH (AT) | 2003-02-13 | — | — | WO | disclosed |
| WO-2001094329-A1 | METHOD FOR THE PRODUCTION OF 2- COUMARONE AND SUBSTITUTED 2-COUMARONES | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171601-A1 | Method for the production of 2-coumarone and substituted 2-coumarones | HAO2, HACL2, HAAO | CYP2D6 29/4885THRB 3943/4885ALDH1A1 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.