SCHEMBL9518474

SCHEMBL9518474

CC1(C)OCc2cc(Cl)cc(C(O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)c2O1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.32
SIRT2 Q8IXJ6 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9521459 0.90 ENPP2 (0.32) ENPP2SIRT2
SCHEMBL9521468 0.85 FLT3 (0.31)
SCHEMBL9521500 0.82 TSHR (0.41) ENPP2
SCHEMBL9518239 0.81
SCHEMBL9519671 0.80 ENPP2 (0.32) ENPP2SIRT2
SCHEMBL10539494 0.79 SIRT2 (0.32) ENPP2SIRT2
SCHEMBL9518318 0.79 ENPP2 (0.31) ENPP2
SCHEMBL9518447 0.76 RORC (0.32)
SCHEMBL9518932 0.74 RORC (0.31)
SCHEMBL30994944 0.73 CYP19A1 (0.39) SIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0269599-B1 Substituted 1H-imidazoles UCB SA (BE) 1993-12-15 EP disclosed
US-4814343-A ANTIISCHEMIC U C B, S.A. (BE) 1989-03-21 US disclosed
EP-0269599-A2 Substituted 1H-imidazoles U C B, S.A. (BE) 1988-06-01 EP disclosed