Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | HMGCR | P04035 | 4/20 | 0.47 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751015 | 0.76 | MEN1 (0.61) | SLC6A4SLC6A3HMGCRABCB1ALDH1A1 | |
| SCHEMBL28694855 | 0.76 | ABCB1 (0.74) | SLC6A4SLC6A3ABCB1ALDH1A1KDM4E | |
| SCHEMBL28697576 | 0.74 | ABCB1 (0.60) | SLC6A4SLC6A3ABCB1ALDH1A1KDM4E | |
| SCHEMBL28673292 | 0.74 | AR (0.51) | SLC6A4SLC6A3ALDH1A1KDM4EMEN1 | |
| SCHEMBL5731755 | 0.74 | KDM4E (0.48) | HMGCRGCGRALDH1A1KDM4EMEN1 | |
| SCHEMBL2260977 | 0.74 | PTGS1 (0.45) | SLC6A4SLC6A3GCGRALDH1A1KDM4E | |
| SCHEMBL9751010 | 0.73 | HMGCR (0.49) | HMGCRABCB1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9521360 | 0.73 | HMGCR (0.57) | HMGCRGCGR | |
| SCHEMBL9750845 | 0.71 | HMGCR (0.56) | HMGCRABCB1ALDH1A1KMT2ALMNA | |
| SCHEMBL10510636 | 0.71 | HMGCR (0.40) | SLC6A4SLC6A3HMGCRGCGRABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |