Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750967 | 0.84 | HMGCR (0.47) | HMGCRABCB1KMT2AMEN1NPC1 | |
| SCHEMBL9750874 | 0.80 | HMGCR (0.41) | HMGCRABCB1ADORA2AADORA1TGFBR1 | |
| SCHEMBL9750852 | 0.79 | HMGCR (0.53) | HMGCRABCB1KMT2AMEN1RAB9A | |
| SCHEMBL9764350 | 0.78 | KDM4E (0.43) | HMGCRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9518177 | 0.78 | HMGCR (0.47) | HMGCR | |
| SCHEMBL6493537 | 0.78 | HMGCR (0.45) | HMGCRBCL2L1BADADORA2AADORA1 | |
| SCHEMBL9751046 | 0.77 | HMGCR (0.55) | HMGCRADORA2AADORA1ALDH1A1 | |
| SCHEMBL9750729 | 0.76 | HMGCR (0.58) | HMGCRKMT2ATGFBR1 | |
| SCHEMBL22188201 | 0.75 | KDM4E (0.42) | HMGCRBCL2L1BADADORA2AADORA1 | |
| SCHEMBL10510636 | 0.74 | HMGCR (0.40) | HMGCRABCB1KMT2AMEN1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |