Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679478 | 1.00 | ACHE (0.58) | ACHEDRD2DRD3POLBADRB3 | |
| SCHEMBL5681817 | 1.00 | ACHE (0.58) | ACHEDRD2DRD3POLBADRB3 | |
| Hydrochloric Acid SCHEMBL8765229 | 0.99 | ACHE (0.57) | ACHEDRD2DRD3POLBADRB3 | |
| Hydrochloric Acid SCHEMBL8765234 | 0.99 | ACHE (0.57) | ACHEDRD2DRD3POLBADRB3 | |
| Hydrochloric Acid SCHEMBL9443687 | 0.99 | ACHE (0.57) | ACHEDRD2DRD3POLBADRB3 | |
| SCHEMBL8765782 | 0.93 | ADRB3 (0.55) | ACHEDRD2DRD3POLBADRB3 | |
| SCHEMBL8766026 | 0.93 | GAA (0.50) | ACHEDRD2DRD3POLBADRB3 | |
| Hydrochloric Acid SCHEMBL8766863 | 0.91 | ADRB3 (0.51) | ACHEDRD2DRD3POLBADRB3 | |
| Hydrochloric Acid SCHEMBL8765354 | 0.89 | GAA (0.51) | ACHEPOLBADRB3GAANPSR1 | |
| SCHEMBL9305655 | 0.88 | BRD4 (0.60) | ACHEDRD2DRD3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347313-B1 | 2-Amino-7-hydroxytetraline ethers | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | claimed |
| US-5159103-A | 2-amino-7-hydroxytetraline ethers | SANOFI (FR) | 1992-10-27 | — | — | US | claimed |
| EP-0347313-A2 | 2-Amino-7-hydroxytetraline ethers | ELF SANOFI (FR) | 1989-12-20 | — | — | EP | claimed |
| EP-0347313-B1 | 2-Amino-7-hydroxytetraline ethers | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| EP-0347313-A2 | 2-Amino-7-hydroxytetraline ethers | ELF SANOFI (FR) | 1989-12-20 | — | — | EP | disclosed |