Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.52 |
| ▸ | GCGR | P47871 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518482 | 0.81 | HMGCR (0.49) | HMGCRSLC6A4SLC6A3PTGDR2CACNA1G | |
| SCHEMBL9518809 | 0.79 | HMGCR (0.43) | HMGCRSLC6A4SLC6A3ABCB1 | |
| SCHEMBL9025275 | 0.74 | GCGR (0.34) | GCGR | |
| SCHEMBL9750906 | 0.73 | HMGCR (0.78) | HMGCR | |
| SCHEMBL9518755 | 0.70 | SLC6A4 (0.47) | HMGCRGCGRSLC6A4SLC6A3ABCB1 | |
| SCHEMBL9750822 | 0.67 | HMGCR (1.00) | HMGCR | |
| SCHEMBL9518613 | 0.65 | HMGCR (0.54) | HMGCRSLC6A4SLC6A3 | |
| SCHEMBL5731755 | 0.64 | KDM4E (0.48) | HMGCRGCGR | |
| SCHEMBL9023815 | 0.63 | GCGR (0.31) | HMGCRGCGR | |
| SCHEMBL9750845 | 0.62 | HMGCR (0.56) | HMGCRPTGDR2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |