Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.55 |
| ▸ | DRD2 | P14416 | 7/20 | 0.55 |
| ▸ | HTR2A | P28223 | 7/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521102 | 0.89 | HTR1A (0.48) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9519156 | 0.80 | HTR1A (0.58) | HTR1ADRD2HTR2A | |
| SCHEMBL4891426 | 0.78 | HTR1A (0.75) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9519864 | 0.77 | HTR2A (0.61) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9522185 | 0.76 | HTR1A (0.54) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9518927 | 0.75 | HTR1A (0.67) | HTR1ADRD2HTR2AADRA1ADRD1 | |
| SCHEMBL11793860 | 0.75 | HTR1A (0.65) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9519161 | 0.75 | HTR1A (0.55) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9520442 | 0.74 | HTR2A (0.53) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9520607 | 0.74 | HTR1A (0.56) | HTR1ADRD2HTR2AADRA1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | claimed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | claimed |
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |