Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785701 | 0.80 | HTR1A (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL9519068 | 0.78 | ALDH1A1 (0.69) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL3454609 | 0.78 | SIGMAR1 (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL9518868 | 0.77 | SIGMAR1 (0.62) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL3976547 | 0.77 | ALDH1A1 (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL31513986 | 0.77 | ALDH1A1 (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL15263292 | 0.76 | ALDH1A1 (0.98) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL9518996 | 0.75 | HTR1A (0.55) | HTR1AHTR2CDRD2HTR2ADRD1 | |
| SCHEMBL10900911 | 0.75 | SIGMAR1 (0.76) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL9521505 | 0.75 | DRD2 (0.64) | HTR1AHTR2CDRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | claimed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | claimed |
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |