Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10464655 | 0.92 | HTR1A (0.51) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9519864 | 0.83 | HTR2A (0.61) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9522185 | 0.82 | HTR1A (0.54) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9520442 | 0.80 | HTR2A (0.53) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9520859 | 0.79 | HTR1A (0.60) | HTR1ADRD2HTR2AADRA1DADRA1B | |
| SCHEMBL11793860 | 0.77 | HTR1A (0.65) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9518921 | 0.76 | HTR2A (0.73) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9518996 | 0.75 | HTR1A (0.55) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9519395 | 0.74 | HTR1A (0.53) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9519254 | 0.73 | HTR2A (0.56) | HTR1ADRD2HTR2ADRD1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |