Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.81 |
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | RXRB | P28702 | 2/20 | 0.58 |
| ▸ | RXRG | P48443 | 2/20 | 0.58 |
| ▸ | CCKAR | P32238 | 14/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | RPA1 | P27694 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520508 | 0.91 | ALOX5 (0.83) | PTGS2ALOX5RXRARXRBRXRG | |
| Tepoxalin SCHEMBL75441 | 0.90 | PTGS2 (1.00) | PTGS2ALOX5RXRARXRBRXRG | |
| Tepoxalin SCHEMBL9519652 | 0.89 | PTGS2 (0.98) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL6309336 | 0.85 | CHRNA7 (0.60) | PTGS2ALOX5CA1CA2CA9 | |
| SCHEMBL9466052 | 0.84 | PTGS2 (0.72) | PTGS2ALOX5RXRARXRBRXRG | |
| Tepoxalin SCHEMBL28256087 | 0.84 | ALOX5 (0.87) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9522599 | 0.81 | ALOX5 (0.83) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9519214 | 0.81 | ALOX5 (0.83) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9989053 | 0.81 | ALOX5 (0.55) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9519177 | 0.80 | ALOX5 (0.82) | PTGS2ALOX5RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5164381-A | Cardiovascular, antiinflammatory | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | disclosed |