Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.83 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.83 |
| ▸ | CCKAR | P32238 | 10/20 | 0.64 |
| ▸ | RXRA | P19793 | 2/20 | 0.59 |
| ▸ | RXRB | P28702 | 2/20 | 0.59 |
| ▸ | RXRG | P48443 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tepoxalin SCHEMBL75441 | 0.91 | PTGS2 (1.00) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL9519062 | 0.91 | PTGS2 (0.81) | ALOX5PTGS2CCKARRXRARXRB | |
| Tepoxalin SCHEMBL9519652 | 0.90 | PTGS2 (0.98) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL9695677 | 0.88 | RXRA (0.74) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL9466052 | 0.85 | PTGS2 (0.72) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL6314914 | 0.85 | PTGS2 (0.69) | ALOX5PTGS2PTGS1 | |
| Tepoxalin SCHEMBL28256087 | 0.85 | ALOX5 (0.87) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL9149353 | 0.84 | PTGS2 (0.60) | ALOX5PTGS2CCKARPTGS1 | |
| SCHEMBL9519214 | 0.82 | ALOX5 (0.83) | ALOX5PTGS2CCKARRXRARXRB | |
| SCHEMBL9522599 | 0.82 | ALOX5 (0.83) | ALOX5PTGS2CCKARRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | claimed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | claimed |