Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519254 | 0.93 | HTR2A (0.56) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL9520828 | 0.83 | HTR1A (0.59) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL10845693 | 0.82 | HTR1A (0.72) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL9519431 | 0.82 | HTR1A (0.58) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL6105283 | 0.80 | HTR1A (0.70) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL9519161 | 0.79 | HTR1A (0.55) | HTR1AHTR2ADRD2ADRA1DADRA1B | |
| SCHEMBL9519156 | 0.78 | HTR1A (0.58) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL9521839 | 0.77 | HTR2A (0.69) | HTR1AHTR7HTR2ADRD2ADRA1D | |
| SCHEMBL6105280 | 0.76 | HTR1A (0.64) | HTR1AHTR7HTR2ADRD2KCNH2 | |
| SCHEMBL6104704 | 0.76 | HTR1A (0.64) | HTR1AHTR7HTR2ADRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |