Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422522 | 0.87 | MEN1 (0.55) | KMT2AALDH1A1MEN1MAPTHTT | |
| SCHEMBL9657786 | 0.83 | CES1 (0.51) | CES1KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9518021 | 0.82 | LMNA (0.56) | ALDH1A1KDM4EMAPTHTTCYP19A1 | |
| SCHEMBL9517953 | 0.82 | TRPV1 (0.51) | KMT2AMEN1MAPTARHDAC3 | |
| SCHEMBL9656899 | 0.81 | TBXAS1 (0.51) | CES1KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9656313 | 0.80 | TBXAS1 (0.53) | CES1KMT2AMEN1KDM4EMAPT | |
| SCHEMBL9519180 | 0.79 | HDAC1 (0.52) | ALDH1A1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9517896 | 0.78 | AR (0.46) | KMT2AALDH1A1MEN1MAPTHTT | |
| SCHEMBL9517930 | 0.76 | PSEN1 (0.54) | KMT2ATDP1ARPGR | |
| SCHEMBL2474197 | 0.76 | CES1 (1.00) | CES1KMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |