Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521056 | 0.93 | DPP8 (0.41) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9519248 | 0.90 | ATM (0.41) | ATMRAB9ANPC1TDP1ECE1 | |
| SCHEMBL9521116 | 0.88 | ATM (0.40) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9518985 | 0.84 | DPP8 (0.40) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9519405 | 0.84 | DPP8 (0.40) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL8758724 | 0.84 | ATM (0.44) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL8759542 | 0.84 | ATM (0.44) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9519787 | 0.83 | ATM (0.41) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9520047 | 0.81 | ATM (0.39) | ATMRAB9ANPC1TDP1ALDH1A1 | |
| SCHEMBL9519209 | 0.81 | HTT (0.40) | ATMRAB9ANPC1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280771-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-5061804-A | 3-thiopyrrolidine as chemical intermediates | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |