Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398790 | 0.88 | SMN1; SMN2 (0.46) | HTTATMBCHETDP1SMN1; SMN2 | |
| SCHEMBL6398117 | 0.88 | SMN1; SMN2 (0.46) | HTTATMBCHETDP1SMN1; SMN2 | |
| SCHEMBL8758724 | 0.85 | ATM (0.44) | HTTATMBCHETDP1MAPT | |
| SCHEMBL8759542 | 0.85 | ATM (0.44) | HTTATMBCHETDP1MAPT | |
| SCHEMBL9519667 | 0.85 | ALDH1A1 (0.37) | HTTATMTDP1SMN1; SMN2MAPT | |
| SCHEMBL9519296 | 0.85 | OPRK1 (0.40) | HTTATMTDP1SMN1; SMN2MAPT | |
| SCHEMBL9519787 | 0.84 | ATM (0.41) | HTTATMBCHETDP1MAPT | |
| SCHEMBL9519248 | 0.84 | ATM (0.41) | HTTATMBCHETDP1NPC1 | |
| SCHEMBL10368216 | 0.84 | SMN1; SMN2 (0.50) | HTTATMBCHETDP1SMN1; SMN2 | |
| SCHEMBL9521116 | 0.83 | ATM (0.40) | HTTATMBCHETDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280771-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-5061804-A | 3-thiopyrrolidine as chemical intermediates | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |