Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.75 |
| ▸ | HTR2A | P28223 | 4/20 | 0.75 |
| ▸ | DRD2 | P14416 | 3/20 | 0.75 |
| ▸ | NOS3 | P29474 | 2/20 | 0.75 |
| ▸ | NOS1 | P29475 | 2/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | HRH1 | P35367 | 3/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519864 | 0.85 | HTR2A (0.61) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL9519268 | 0.80 | HTR2A (0.53) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL9522030 | 0.80 | HTR2A (0.53) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL3580702 | 0.80 | HTR1A (0.68) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL9518921 | 0.78 | HTR2A (0.73) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL3583906 | 0.74 | HRH3 (0.71) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL9522185 | 0.73 | HTR1A (0.54) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL9519068 | 0.73 | ALDH1A1 (0.69) | HTR1AHTR2ADRD2ADRA1AHTR2C | |
| SCHEMBL13438221 | 0.73 | HRH3 (1.00) | HTR1AHTR2ADRD2NOS3NOS1 | |
| SCHEMBL13438225 | 0.73 | HRH3 (1.00) | HTR1AHTR2ADRD2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |