Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519268 | 0.89 | HTR2A (0.53) | HTR2AHTR2CHTR2BCYP2C9HTR1A | |
| SCHEMBL9519864 | 0.88 | HTR2A (0.61) | HTR2AHTR2CHTR2BCYP2C9HTR1A | |
| SCHEMBL9518921 | 0.82 | HTR2A (0.73) | HTR2AHTR2CHTR2BHTR1ADRD2 | |
| SCHEMBL9519273 | 0.80 | HTR1A (0.75) | HTR2AHTR2CHTR2BHTR1ADRD2 | |
| SCHEMBL9521102 | 0.80 | HTR1A (0.48) | HTR2AHTR2CCYP2C9HTR1ADRD2 | |
| SCHEMBL9522185 | 0.77 | HTR1A (0.54) | HTR2AHTR2CHTR2BCYP2C9HTR1A | |
| SCHEMBL9519068 | 0.75 | ALDH1A1 (0.69) | HTR2AHTR2CHTR2BHTR1ADRD2 | |
| SCHEMBL9520442 | 0.75 | HTR2A (0.53) | HTR2AHTR2CHTR2BCYP2C9HTR1A | |
| SCHEMBL9519161 | 0.72 | HTR1A (0.55) | HTR2AHTR2CCYP2C9HTR1ADRD2 | |
| SCHEMBL9520828 | 0.72 | HTR1A (0.59) | HTR2AHTR2CHTR2BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |