Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | PTAFR | P25105 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522620 | 1.00 | TBXAS1 (0.58) | TBXAS1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL9519344 | 1.00 | TBXAS1 (0.58) | TBXAS1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL8693544 | 0.83 | TBXAS1 (0.56) | TBXAS1GAAALDH1A1 | |
| SCHEMBL9522139 | 0.83 | CES2 (0.59) | KMT2ACYP1B1RAB9AGAAALDH1A1 | |
| SCHEMBL8693546 | 0.83 | TBXAS1 (0.56) | TBXAS1GAAALDH1A1 | |
| SCHEMBL9522133 | 0.83 | CES2 (0.59) | KMT2ACYP1B1RAB9AGAAALDH1A1 | |
| SCHEMBL9522136 | 0.83 | CES2 (0.59) | KMT2ACYP1B1RAB9AGAAALDH1A1 | |
| SCHEMBL10398977 | 0.83 | PTAFR (0.60) | TBXAS1KMT2ACYP1A1CYP1A2CYP1B1 | |
| Bicarbonate SCHEMBL9520704 | 0.83 | TBXAS1 (0.58) | TBXAS1KMT2ACYP1A1CYP1A2CYP1B1 | |
| Bicarbonate SCHEMBL9519216 | 0.83 | TBXAS1 (0.58) | TBXAS1KMT2ACYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |