Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519806 | 0.92 | ALDH1A1 (0.39) | DPP8DPP9ALDH1A1MAPTGAA | |
| SCHEMBL9519170 | 0.88 | DPP8 (0.38) | DPP8DPP9ALDH1A1MAPTGAA | |
| SCHEMBL9519403 | 0.87 | DPP8 (0.37) | DPP8DPP9ALDH1A1MAPTGAA | |
| SCHEMBL9518937 | 0.84 | ALDH1A1 (0.38) | ALDH1A1MAPTHPGDTDP1CCR5 | |
| SCHEMBL9520697 | 0.83 | DPP8 (0.46) | DPP8DPP9ALDH1A1MAPTGAA | |
| SCHEMBL7862659 | 0.82 | CYP2C9 (0.41) | DPP8DPP9MAPTGAAKMT2A | |
| SCHEMBL10363296 | 0.81 | MAOB (0.42) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL9522365 | 0.80 | ALDH1A1 (0.36) | DPP8DPP9ALDH1A1MAPTGAA | |
| SCHEMBL8782246 | 0.80 | HTT (0.40) | DPP8DPP9ALDH1A1MAPTHPGD | |
| SCHEMBL9078142 | 0.80 | HTT (0.40) | DPP8DPP9ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280771-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-5061804-A | 3-thiopyrrolidine as chemical intermediates | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4963543-A | BACTERICIDES, TREATING INFECTIOUS DISEASES; THIENAMYCINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0280771-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |