Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.62 |
| ▸ | GABRP | O00591 | 3/20 | 0.62 |
| ▸ | GABRD | O14764 | 3/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.62 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.62 |
| ▸ | GABRE | P78334 | 3/20 | 0.62 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.62 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684191 | 0.82 | KMT2A (0.71) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| SCHEMBL8844868 | 0.81 | KMT2A (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| SCHEMBL30289323 | 0.81 | KMT2A (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| SCHEMBL9684958 | 0.81 | KMT2A (0.69) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| Nordazepam SCHEMBL8090999 | 0.77 | PDE4D (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| Nordazepam SCHEMBL29354494 | 0.77 | PDE4D (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| Nordazepam SCHEMBL31000330 | 0.77 | PDE4D (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| Nordazepam SCHEMBL78453 | 0.77 | PDE4D (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| SCHEMBL11827239 | 0.76 | PGR (0.67) | KMT2AMEN1PDE4DCNR1NTSR1 | |
| Delorazepam SCHEMBL29375434 | 0.76 | GABRA1 (1.00) | KMT2AMEN1PDE4DCNR1NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | claimed |
| EP-0574781-A2 | 2-Amino-5-heterocyclic-substituted-1,4-benzodiazepines and their use in the treatment of aids | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-22 | — | — | EP | disclosed |
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | disclosed |