Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9518269 | 0.98 | HTR2A (0.43) | HTR2ASIGMAR1ADRA2AMAOBMAOA | |
| Hydrochloric Acid SCHEMBL9515939 | 0.84 | HTR2A (0.37) | HTR2ASIGMAR1ADRA2AMAOBDRD2 | |
| Hydrochloric Acid SCHEMBL9519799 | 0.84 | HTR2A (0.50) | HTR2AMAOBMAOATAAR1KDM1A | |
| Hydrochloric Acid SCHEMBL9519876 | 0.81 | HTR2A (0.44) | HTR2ASIGMAR1ADRA2AKDM1A | |
| SCHEMBL9515982 | 0.78 | SLC6A4 (0.39) | SIGMAR1ADRA2ATAAR1 | |
| SCHEMBL6950437 | 0.77 | SIGMAR1 (0.36) | SIGMAR1ADRA2ADRD2DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL10471562 | 0.77 | SLC6A2 (0.38) | HTR2ASIGMAR1ADRA2ADRD2DRD1 | |
| Hydrochloric Acid SCHEMBL9517486 | 0.76 | KDM1A (0.40) | HTR2AKDM1A | |
| Hydrochloric Acid SCHEMBL9515919 | 0.76 | KDM1A (0.40) | HTR2AKDM1A | |
| SCHEMBL9515942 | 0.75 | CYP2D6 (0.36) | SIGMAR1ADRA2ADRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361577-B1 | TETRAHYDRONAPHTHALENE AND INDANE DERIVATIVES | AKZO N.V. (NL) | 1993-05-05 | — | — | EP | disclosed |
| US-4980354-A | Tetrahydronaphthalene and indane derivatives | AKZO N.V. (NL) | 1990-12-25 | — | — | US | disclosed |
| EP-0361577-A1 | Tetrahydronaphthalene and indane derivatives | AKZO N.V. (NL) | 1990-04-04 | — | — | EP | disclosed |