Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580376 | 0.77 | ADRA2A (0.36) | SIGMAR1ADRA2ANOTUMATMALDH1A1 | |
| SCHEMBL9519923 | 0.77 | HTR2A (0.44) | SIGMAR1ADRA2AATMDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL10471562 | 0.76 | SLC6A2 (0.38) | SIGMAR1ADRA2AATMALDH1A1DRD2 | |
| Hydrochloric Acid SCHEMBL9518269 | 0.75 | HTR2A (0.43) | SIGMAR1ADRA2AATMDRD2DRD1 | |
| SCHEMBL28230100 | 0.75 | ALDH1A1 (0.40) | SIGMAR1NOTUMATMALDH1A1SMN1; SMN2 | |
| SCHEMBL9515942 | 0.75 | CYP2D6 (0.36) | SIGMAR1ADRA2AATMDRD2DRD1 | |
| SCHEMBL9515982 | 0.74 | SLC6A4 (0.39) | SIGMAR1ADRA2A | |
| Hydrochloric Acid SCHEMBL9519827 | 0.73 | CYP2D6 (0.35) | SIGMAR1ADRA2AATMKMT2ASMN1; SMN2 | |
| SCHEMBL12203619 | 0.73 | ADRA2A (0.38) | SIGMAR1ADRA2ANOTUMATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL9515939 | 0.72 | HTR2A (0.37) | SIGMAR1ADRA2ADRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |