Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.40 |
| ▸ | PPARA | Q07869 | 17/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721194 | 0.94 | PPARA (0.37) | PPARGPPARAPPARDLIPGFFAR1 | |
| SCHEMBL9878676 | 0.81 | PPARA (0.36) | PPARGPPARAPPARDFFAR1 | |
| SCHEMBL9520686 | 0.79 | PPARG (0.44) | PPARGPPARAPPARD | |
| SCHEMBL9521721 | 0.78 | PPARG (0.44) | PPARGPPARAPPARD | |
| SCHEMBL9520439 | 0.78 | PPARG (0.43) | PPARGPPARAPPARDFFAR1CYP2C9 | |
| SCHEMBL9521124 | 0.78 | PPARG (0.38) | PPARGPPARAPPARDKCNH2 | |
| SCHEMBL9521119 | 0.78 | PPARG (0.38) | PPARGPPARAPPARDKCNH2 | |
| SCHEMBL7871522 | 0.77 | PPARG (0.46) | PPARGPPARAPPARDFFAR1CYP2C9 | |
| SCHEMBL7871527 | 0.77 | PPARG (0.46) | PPARGPPARAPPARDFFAR1CYP2C9 | |
| SCHEMBL7722467 | 0.75 | PPARG (0.42) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |