Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 4/20 | 0.37 |
| ▸ | F3 | P13726 | 4/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519693 | 1.00 | TBXAS1 (0.39) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL10399010 | 0.85 | CES2 (0.40) | TBXAS1PTGS1PTGS2CES2CES1 | |
| Bicarbonate SCHEMBL9520434 | 0.85 | CES2 (0.40) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL10399158 | 0.85 | CES2 (0.40) | TBXAS1PTGS1PTGS2CES2CES1 | |
| Bicarbonate SCHEMBL9519696 | 0.85 | CES2 (0.40) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL10399012 | 0.85 | CES2 (0.40) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL9519486 | 0.85 | HTR7 (0.47) | PTGS1PTGS2LMNAF7F3 | |
| SCHEMBL9519610 | 0.81 | PTGS1 (0.45) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL10398868 | 0.81 | PTGS1 (0.45) | TBXAS1PTGS1PTGS2CES2CES1 | |
| SCHEMBL9519613 | 0.81 | PTGS1 (0.45) | TBXAS1PTGS1PTGS2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |