Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 16/20 | 0.49 |
| ▸ | PPARA | Q07869 | 14/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721259 | 0.91 | PPARG (0.45) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL27256704 | 0.83 | KDM4E (0.49) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL9008052 | 0.80 | KDM4E (0.56) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL7879558 | 0.80 | KDM4E (0.56) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL4034559 | 0.79 | KDM4E (0.73) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL14373654 | 0.77 | KDM4E (0.59) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL5123862 | 0.77 | PPARA (0.63) | PPARGPPARAPPARD | |
| SCHEMBL14265738 | 0.77 | PPARA (0.63) | PPARGPPARAPPARD | |
| SCHEMBL9520439 | 0.77 | PPARG (0.43) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL4031089 | 0.76 | KDM4E (0.65) | KDM4EPPARGPPARAHPGDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| CN-1036572-A | Thiazolidinedione derivatives for lowering blood glucose | PFIZER (US) | 1989-10-25 | — | — | CN | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |