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Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL9520970

ClC1(Cl)c2ccccc21.N

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ S100A4 P26447 1/20 0.44
▸ CACNB4 O00305 1/20 0.39
▸ CACNA1A O00555 1/20 0.39
▸ CACNA1G O43497 1/20 0.39
▸ CACNG3 O60359 1/20 0.39
▸ CACNA1F O60840 1/20 0.39
▸ CACNA1H O95180 1/20 0.39
▸ CACNB3 P54284 1/20 0.39
▸ CACNA2D1 P54289 1/20 0.39
▸ CACNG7 P62955 1/20 0.39
▸ CACNA1B Q00975 1/20 0.39
▸ CACNA1D Q01668 1/20 0.39
▸ CACNB1 Q02641 1/20 0.39
▸ CACNG1 Q06432 1/20 0.39
▸ CACNB2 Q08289 1/20 0.39
▸ CACNA1S Q13698 1/20 0.39
▸ CACNA1C Q13936 1/20 0.39
▸ CACNA1E Q15878 1/20 0.39
▸ CACNA2D4 Q7Z3S7 1/20 0.39
▸ CACNA2D3 Q8IZS8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27535794 0.97 S100A4 (0.42) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL8369793 0.96 S100A4 (0.46) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL29612259 0.80 S100A4 (0.65) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL6836847 0.80 S100A4 (0.65) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL27500046 0.78 S100A4 (0.62) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL28216738 0.78 S100A4 (0.62) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL2826156 0.76 MAPT (0.42) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL8984697 0.74 NOX1 (0.44) S100A4CACNB4CACNA1ACACNA1GCACNG3
SCHEMBL26798934 0.74 HTR2A (0.50) S100A4LMNAALDH1A1PDK2
SCHEMBL10695558 0.72 CYP1A2 (0.40) S100A4CACNB4CACNA1ACACNA1GCACNG3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102388060-A Actagardine derivatives NOVACTA BIOSYSTEMS LTD 2012-03-21 — — CN claimed
CN-105085429-A Heteroaromatic derivative and application thereof to medicament GUANGDONG HEC PHARMACEUTICAL 2015-11-25 — — CN disclosed
CN-104918617-A As P2X7Heterocyclic amide derivatives of receptor antagonists ACTELION PHARMACEUTICALS LTD 2015-09-16 — — CN disclosed
CN-101370765-B Method for selectively producing primary amine SUMITOMO CHEMICAL CO 2013-03-13 — — CN disclosed
CN-102388060-A Actagardine derivatives NOVACTA BIOSYSTEMS LTD 2012-03-21 — — CN disclosed
CN-101137381-B 2-anilino-3 HOFFMANN LA ROCHE 2011-07-27 — — CN disclosed
CN-101506148-A Inhibitors for GLYT-1 HOFFMANN LA ROCHE (CH) 2009-08-12 — — CN disclosed
CN-101370765-A Method for selectively producing primary amine SUMITOMO CHEMICAL CO (JP) 2009-02-18 — — CN disclosed
CN-101137381-A 2-anilino-3, 4-dihydro-quinazolines as 5HT5AUse of receptor antagonists HOFFMANN LA ROCHE (CH) 2008-03-05 — — CN disclosed
CN-1186332-C Novel thyroid receptor ligands and method II KAROBIO AB (SE) 2005-01-26 — — CN disclosed
CN-1337953-A Novel thyroid receptor ligands and method II KAROBIO AB (SE) 2002-02-27 — — CN disclosed
EP-0346239-B1 PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE-POULENC SANTE (FR) 1993-06-02 — — EP disclosed
EP-0346239-A1 Phenothiazine derivatives, their preparation and pharmaceutical compositions containing them RHONE-POULENC SANTE (FR) 1989-12-13 — — EP disclosed
CN-87105612-A PYRIMIDINE DERIVATIVES — 1988-03-16 — — CN disclosed