Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GRN | P28799 | 1/20 | 0.30 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879351 | 0.91 | HRH2 (0.31) | KDM4EGABRA5 | |
| SCHEMBL9521922 | 0.83 | MAPK1 (0.44) | KDM4EALDH1A1GABRA5L3MBTL1GAA | |
| SCHEMBL9521091 | 0.79 | GABRA5 (0.36) | KDM4EALDH1A1GABRA5PTPRCGRIN2B | |
| SCHEMBL29209521 | 0.76 | GRIN2B (0.41) | KDM4EALDH1A1GABRA5GRIN2B | |
| SCHEMBL29209494 | 0.72 | GAA (0.51) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL9521098 | 0.71 | KDM4E (0.34) | KDM4EALDH1A1GABRA5PTPRCGRIN2B | |
| SCHEMBL14740772 | 0.67 | HCAR2 (0.44) | KDM4EALDH1A1PTPRC | |
| SCHEMBL5158637 | 0.66 | PLOD2 (0.59) | ALDH1A1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL1200949 | 0.66 | NPC1 (0.59) | KDM4EALDH1A1L3MBTL1HDAC1HDAC8 | |
| SCHEMBL27444162 | 0.64 | MAPK1 (0.38) | KDM4EL3MBTL1HDAC6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |