Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521084 | 0.83 | KDM4E (0.32) | KDM4EL3MBTL1ALDH1A1GAAKMT2A | |
| SCHEMBL1439028 | 0.76 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL8682205 | 0.75 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL30792011 | 0.75 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL31435350 | 0.74 | MAPK1 (0.56) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL3759509 | 0.73 | MAPK1 (0.46) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL480126 | 0.73 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL2382926 | 0.73 | MAPK1 (0.54) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL17893894 | 0.73 | MAPK1 (0.58) | MAPK1KDM4EL3MBTL1CA12CA1 | |
| SCHEMBL3715093 | 0.73 | MAPK1 (0.54) | MAPK1KDM4EL3MBTL1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |