Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521080 | 1.00 | MAOB (0.45) | MAOBNPC1SMN1; SMN2LMNACES2 | |
| SCHEMBL9518925 | 0.88 | GPR52 (0.47) | NPC1SMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL9523136 | 0.87 | CES2 (0.53) | MAOBNPC1CES2CES1KMT2A | |
| SCHEMBL9522407 | 0.87 | CES2 (0.53) | MAOBNPC1CES2CES1KMT2A | |
| SCHEMBL9521346 | 0.86 | CA1 (0.49) | NPC1SMN1; SMN2CES2CES1MAPT | |
| SCHEMBL10398891 | 0.84 | MAOB (0.51) | MAOBNPC1SMN1; SMN2LMNACES2 | |
| SCHEMBL10399176 | 0.84 | MAOB (0.51) | MAOBNPC1SMN1; SMN2LMNACES2 | |
| SCHEMBL10398890 | 0.84 | MAOB (0.51) | MAOBNPC1SMN1; SMN2LMNACES2 | |
| Bicarbonate SCHEMBL9521138 | 0.84 | MAOB (0.48) | MAOBNPC1SMN1; SMN2LMNACES2 | |
| Bicarbonate SCHEMBL9521090 | 0.84 | MAOB (0.48) | MAOBNPC1SMN1; SMN2LMNACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |